Anti-GR

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-491A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-491A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-491A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action:... more
Product information "Anti-GR"
Protein function: Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. [The UniProt Consortium]
Keywords: Anti-GR, Anti-GRL, Anti-NR3C1, Anti-Glucocorticoid receptor, Anti-Nuclear receptor subfamily 3 group C member 1
Supplier: Bethyl Laboratories
Supplier-Nr: A303-491A

Properties

Application: WB, IP, IHC, ChIP-Seq
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Sheep)
Immunogen: synthetic peptide. The epitope recognized by A303-491A-T maps to a region between residue 150 and 200 of human Glucocorticoid Receptor using the numbering given in entry NP_000167.1 (GeneID 2908).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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