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Gastrokine 1 (GKN1),a stomach-specic protein also known as 18 kDa antrum mucosa protein (AMP-18) or foveolin,belongs to the gastrokine family of gastric mucus cell-secreted proteins. The human GKN1 gene has been localized in a region of chromosome 2p13 of about 6 kb and contains 6 exons. GKN1 is expressed only in normal human stomach,but is absent from gastric adenocarcinomas,gastro-esophageal adenocarcinoma cell lines,and other normal and tumor gastro-intestinal tissues. GKN1may play an important role in normal gastric function and may be a gastric tumour suppressor. Protein function: Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. [The UniProt Consortium]
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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