Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-930A-T 10 µl (10 µg) -

3 - 9 business days*

A301-930A 100 µl (100 µg) -

3 - 9 business days*

Protein function: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved... more
Product information "Anti-GEF-H1"
Protein function: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF- alpha secretion in macrophage upon stimulation by bacterial peptidoglycans, acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability. Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons. [The UniProt Consortium]
Keywords: Anti-GEF-H1, Anti-ARHGEF2, Anti-KIAA0651, Anti-Microtubule-regulated Rho-GEF, Anti-Guanine nucleotide exchange factor H1, Anti-Rho guanine nucleotide exchange factor 2, Anti-Proliferating cell nucleolar antigen p40
Supplier: Bethyl Laboratories
Supplier-Nr: A301-930A


Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Small-eared Galago, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-930A-T maps to a region between residue 850 and 900 of human guanine nucleotide exchange factor H1 using the numbering given in entry CAH72629.1 (GeneID 9181).
Format: Antigen Affinity Purified

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Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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