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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V3236SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. Plakoglobin, also known as junction plakoglobin... more
Product information "Anti-Gamma Catenin / Plakoglobin, clone CTNG/1664"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Plakoglobin, also known as junction plakoglobin or gamma Catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to beta-catenin. It is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in Gamma Catenin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.Gamma Catenin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent common to submembranous plaques in both of these structures, which are located at the intercalated disc (ICD) of cardiomyocytes. It links cadherins to the actin cytoskeleton. Gamma Catenin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble desmosomes. [Wiki] Protein function: Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. [The UniProt Consortium]
Keywords: | Anti-JUP, Anti-CTNNG, Anti-Desmoplakin-3, Anti-Catenin gamma, Anti-Desmoplakin III, Anti-Junction plakoglobin, Gamma Catenin Antibody / Plakoglobin |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V3236SAF |
Properties
Application: | IF, WB, FC, IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | CTNG/1664 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant human protein was used as the immunogen for the Gamma Catenin antibody. |
Format: | Purified |
Database Information
KEGG ID : | K10056 | Matching products |
UniProt ID : | P14923 | Matching products |
Gene ID | GeneID 3728 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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