Anti-Gamma Catenin / Plakoglobin, clone 11E4.

Anti-Gamma Catenin / Plakoglobin, clone 11E4.
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3204-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V3204-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. It recognizes a... more
Product information "Anti-Gamma Catenin / Plakoglobin, clone 11E4."
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. It recognizes a protein of 80-87kDa, identified as gamma-Catenin or Plakoglobin. The catenins (alpha, beta, gamma and delta) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy. Protein function: Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. [The UniProt Consortium]
Keywords: Anti-JUP, Anti-CTNNG, Anti-Desmoplakin-3, Anti-Catenin gamma, Anti-Desmoplakin III, Anti-Junction plakoglobin, Gamma Catenin Antibody / Plakoglobin
Supplier: NSJ Bioreagents
Supplier-Nr: V3204-20UG

Properties

Application: IF, WB, IP
Antibody Type: Monoclonal
Clone: 11E4.
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse
Immunogen: Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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