Anti-Gamma Catenin / Plakoglobin, clone CTNG/1483

Anti-Gamma Catenin / Plakoglobin, clone CTNG/1483
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3235SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Plakoglobin, also known as junction plakoglobin... more
Product information "Anti-Gamma Catenin / Plakoglobin, clone CTNG/1483"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to beta-catenin. It is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in Plakoglobin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.Plakoglobin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent common to submembranous plaques in both of these structures, which are located at the intercalated disc (ICD) of cardiomyocytes. It links cadherins to the actin cytoskeleton. Plakoglobin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble desmosomes. [Wiki] Protein function: Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. [The UniProt Consortium]
Keywords: Anti-JUP, Anti-CTNNG, Anti-Desmoplakin-3, Anti-Catenin gamma, Anti-Desmoplakin III, Anti-Junction plakoglobin, Gamma Catenin Antibody / Plakoglobin
Supplier: NSJ Bioreagents
Supplier-Nr: V3235SAF-100UG

Properties

Application: IF, WB, FC, IHC (paraffin)
Antibody Type: Monoclonal
Clone: CTNG/1483
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human protein was used as the immunogen for the Plakoglobin antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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