Anti-Gamma Catenin

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Catenin gamma, also known as Junction plakoglobin (JUP) or Plakoglobin (PKGB), is a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. Catenin beta and gamma, vertebrate homologs of Drosophila armadillo, function in cell adhesion and the Wnt signaling pathway. Catenin gamma may have distinct roles in Wnt signaling and cancer via differential effects on downstream target genes. Protein function: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. [The UniProt Consortium]