Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G1015-41L.100 | 100 µg | - | - |
3 - 19 business days* |
962.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
GABAB R1 is a multispan member of the GABA-B receptor subfamily, GPCR-3 family of proteins. It... more
Product information "Anti-GABBR1 (Gamma-aminobutyric Acid Type B Receptor Subunit 1, GABA-B Receptor 1, GABA-B-R1, GABA-B"
GABAB R1 is a multispan member of the GABA-B receptor subfamily, GPCR-3 family of proteins. It forms an obligatory heterodimer with GABA-BR2, creating a G-protein metabotropic GABA receptor that inhibits adenylyl cyclase activity and activates K+ channels. Presynaptically, this blocks neurotransmitter release, postsynaptically, it lowers neuron excitability. Rat GABAB R1 is 991aa in length. It is a 7-transmembrane glycoprotein that contains a 16aa signal sequence, an extended N-terminal extracellular region aa17-590 that contains two SUSHI domains aa29-158 and a long C-terminal cytoplasmic domain aa885-991. There are several splice variants with predicted molecular weights ranging from 90 to 111kD and multiple glycosylation sites. The 991aa isoform described above is called GABAB R1e (R1e). There is also a 960aa, 130kD isoform that shows a deletion of aa771-801. This variant (R1a) is associated with postsynaptic membranes. A third isoform (R1b) is 844aa in length and 100kD in size, and possesses both a deletion of aa771-801, and a 47aa substitution for aa1-163. This variant is presynaptic in location. Two other isoforms are variants of GABAB R1b. Each show the same N-terminal substitution, with a fourth isoform (R1c) retaining aa771-801, and a fifth isoform (R1d) deleting aa771-801, coupled to a 25aa substitution for aa935-991. Over aa17-586, rat GABAB R1e/a shares 99% aa identity with both mouse and human GABAB R1. Applications: Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml, Immunohistochemistry: 5-15ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-Gb1, Anti-Gabbr1, Anti-GABABR1, Anti-GABA-BR1, Anti-GABA-B-R1, Anti-GABA-B receptor 1, Anti-Gamma-aminobutyric acid type B receptor subunit 1 |
Supplier: | United States Biological |
Supplier-Nr: | G1015-41L |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Sheep |
Species reactivity: | mouse, rat |
Immunogen: | Recombinant corresponding to aa17-586 from rat GABBR1 expressed in CHO cell line. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04615 | Matching products |
UniProt ID : | Q9Z0U4 | Matching products |
Gene ID | GeneID 81657 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed