99 products were found matching "K04615"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. GABBR2 antibody recognizes gamma-aminobutyric acid type B receptor subunit 2, a critical component of the GABA-B receptor complex that mediates inhibitory neurotransmission in the central nervous system. The GABA-B receptor is a...

GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission. Functional...

SKF 97541 is a GABAB receptor agonist. It reduces forskolin-induced cAMP accumulation in rat cortical slices when used at concentrations of 30 and 100 µM. SKF 97541 reduces excitatory postsynaptic potentials (EPSPs) induced by bicuculline (Cay11727) in rat striatal slices (EC50 = 0.092 µM), an effect that can be...

(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM). It induces norepinephrine release from isolated rat atria (IC50 = 4.5 µM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice. It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats. (±)-Baclofen also reduces...

CGP 54626 is a selective antagonist of the GABAB receptor with an IC50 value of 4 nM. It can be used to investigate the role of GABAB receptors in neurological signaling.Formal Name: P-(cyclohexylmethyl)-P-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-phosphinic acid, monohydrochloride. CAS...

Saclofen is a sulfonic analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50 = 7.8 µM). This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in...

(+)-Baclofen is a GABAB receptor agonist. In vivo, (+)-baclofen (1 and 3 mg/kg) increases latency to paw or tail withdrawal in the hot-plate test in mice. (+)-Baclofen (3 mg/kg) also reduces the number of lever responses for alcohol in Sardinian alcohol-preferring rats.Formal Name:...

CGP 55845 is a GABAB receptor antagonist (Ki = 4.5 nM). It increases electrical stimulation-induced GABA release in the absence and presence of the GABAB receptor agonist (-)-baclofen, as well as glutamate release in the presence of (-)-baclofen, in rat cerebral cortex slices (EC50s = 8.3, 25, and 14 nM,...

Protein function: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine...

Protein function: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine...

Anti-GABA(A) Receptor 2 pS783 Antibody is directed against rat phosphorylated GABA(A) Receptor 2. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the GABAB R2 band is completely blocked by ?-phosphatase treatment. Reactivity is expected from the...

Anti-GABA(A) Receptor 1 pS923 Antibody is directed against rat phosphorylated GABA(A) Receptor 2. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the GABAB R1 band is completely blocked by ?-phosphatase treatment. Reactivity is expected from the...