Anti-Focal adhesion kinase 1 (Biotin)

Anti-Focal adhesion kinase 1 (Biotin)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
316216.50 50 µg - -

3 - 19 business days*

470.00€
316216.100 100 µg - -

3 - 19 business days*

682.00€
 
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration,... more
Product information "Anti-Focal adhesion kinase 1 (Biotin)"
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation, required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC, this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-FAK, Anti-PTK2, Anti-FRNK, Anti-FADK 1, Anti-p125FAK, Anti-pp125FAK, EC=2.7.10.2, Anti-p41/p43FRNK, Anti-Focal adhesion kinase 1, Anti-Protein-tyrosine kinase 2, Anti-Focal adhesion kinase-related nonkinase
Supplier: United States Biological
Supplier-Nr: 316216

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: Biotin
Host: Rabbit
Species reactivity: chicken
Immunogen: Recombinant chicken Focal adhesion kinase 1 protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Focal adhesion kinase 1 (Biotin)"
Write a review
or to review a product.
Viewed