191 products were found matching "K05725"!

Narmafotinib is an inhibitor of focal adhesion kinase (FAK). It inhibits autophosphorylation of FAK at tyrosine 397 in MDA-MB-231 breast cancer cells (IC50 = 7 nM). Narmafotinib (80 mg/kg), in combination with bevacizumab, reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer. It also induces...

A PROTAC that drives FAK degradation, reduces the migration and invasion of MDA-MB-231 cells at 50 and 100 nM, respectively. SMILES: O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCOC(C=C4)=CC=C4NC(N=C5NCC6=CC(N(C)[S](C)(=O)=O)=CC=C6)=NC=C5C(F)(F)F)=O. InChi Code:...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-FAK (Tyr576/Tyr577) antibody detects focal adhesion kinase 1 when phosphorylated at tyrosine residues 576 and 577. Focal adhesion kinase, encoded by the PTK2 gene, is a cytoplasmic tyrosine...

PTK2(protein tyrosine kinase 2) Homo sapiens This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine...

PTK2(protein tyrosine kinase 2) Homo sapiens This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine...

Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified...

Rabbit Polyclonal PTK2 Antibody against Human protein tyrosine kinase 2. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000022607: 96%,...

Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption....

CEP-37440 is a dual inhibitor of focal adhesion kinase 1 (FAK1, IC50s = 2.0 and 80 nM for in vitro enzyme and cellular inhibition, respectively) and anaplastic lymphoma kinase (ALK, IC50s = 3.1 and 22 nM for in vitro enzyme and cellular inhibition, respectively). It blocks the proliferation of inflammatory and...

GSK2256098 is an inhibitor of focal adhesion kinase (FAK). It is selective for FAK, inhibiting only FAK greater than 50% in a panel of 261 kinases. GSK2256098 inhibits FAK autophosphorylation at tyrosine 397 (Y397) in OVCAR8 ovarian, U87MG glioblastoma, and A549 lung cancer cell lines (IC50s = 15, 8.5, and 12 nM,...

PND1186 is a potent reversible focal adhesion kinase (FAK) inhibitor with an IC50 value of 1.5 nM against the recombinant enzyme and 100 nM in breast carcinoma cells. It promotes 4T1 breast carcinoma and ID8 ovarian carcinoma cell apoptosis when grown in anchorage-independent 3D cultures but had limited efficacy in...

Focal adhesion kinases (FAK) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are over-expressed in many types of cancer. FAK inhibitor 14 is a direct inhibitor of FAK1 autophosphorylation, blocking...