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The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. Protein function: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. [The UniProt Consortium]
Keywords:
Anti-CD16b, Anti-CD16B, Anti-FcRIII, Anti-FcR-10, Anti-FCGR3B, Anti-FcRIIIb, Anti-Fc-gamma RIII, Anti-Fc-gamma RIIIb, Anti-Fc-gamma RIII-beta, Anti-IgG Fc receptor III-1, Anti-Low affinity immunoglobulin gamma Fc region receptor III-B, FCGR3B Polyclonal A
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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