Anti-FBXL11

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG66414.50	50 µg		-	-	6 - 14 business days*		520.00€

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Protein function: Histone demethylase that specifically demethylates 'Lys- 36' of histone H3,... more

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Product information "Anti-FBXL11"

Protein function: Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK- ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). [The UniProt Consortium]

Keywords:	Anti-KDM2A, Anti-CXXC8, Anti-F-box protein FBL7, Anti-F-box protein Lilina, Anti-F-box/LRR-repeat protein 11, Anti-Lysine-specific demethylase 2A, Anti-CXXC-type zinc finger protein 8, Anti-[Histone-H3]-lysine-36 demethylase 1A
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG66414

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Goat
Species reactivity:	human (Expected: mouse, rat, bovine, dog, swine)
Immunogen:	Synthetic peptide around the internal region of Human FBXL11. (C-PRKDRQVHLTHFELE, NP_036440.1)
MW:	133 kD
Format:	Ammonium Sulfate Precipitated