Anti-FAK (Focal adhesion kinase 1), Rabbit Monoclonal (RM472)

FAK1 (Focal Adhesion Kinase 1) is a non-receptor protein tyrosine kinase that is involved in the regulation of cell adhesion, migration, and survival. It is a member of the Src family of kinases. FAK1 is activated by binding to integrins, which are transmembrane proteins that mediate the attachment of cells to the extracellular matrix. When FAK1 is activated, it phosphorylates a number of downstream targets, including paxillin, tensin, and the small GTPase Ras. These phosphorylation events lead to the activation of a number of signaling pathways, including the MAPK pathway, the PI3K-AKT pathway, and the NF-kappaB pathway. The MAPK pathway is involved in the regulation of cell migration, survival, and proliferation. The PI3K-AKT pathway is involved in the regulation of cell survival and metabolism. The NF-kappaB pathway is involved in the regulation of inflammation and immunity.