Anti-DNMT3b (Clone:ABM1C25 )

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Discount	Price
ABE-10-7001-25	25 µg		-		3 - 11 business days*		15 %	149.00€ 126.65€
ABE-10-7001-100	100 µg		-		3 - 11 business days*		15 %	418.00€ 355.30€

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Protein function: Required for genome-wide de novo methylation and is essential for the... more

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Product information "Anti-DNMT3b (Clone:ABM1C25 )"

Protein function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). [The UniProt Consortium]

Keywords:	Anti-DNMT3B, Anti-Dnmt3b, Anti-M.HsaIIIB, EC=2.1.1.37, Anti-DNA MTase HsaIIIB, Anti-DNA methyltransferase HsaIIIB, Anti-DNA (cytosine-5)-methyltransferase 3B, Monoclonal Antibody to DNMT3b (Clone:ABM1C25 )
Supplier:	Abeomics
Supplier-Nr:	10-7001

Properties

Application:	WB
Antibody Type:	Monoclonal
Clone:	ABM1C25
Conjugate:	No
Host:	Mouse
Species reactivity:	human
Immunogen:	Full length recombinant protein of DNMT3b was used as the immunogen for this antibody.
Format:	Purified