36 products were found matching "K17399"!

SGI-1027 is an inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B (IC50s = 12.5, 8, and 7.5 µM, respectively, with Poly(dI-dC) as the substrate). It has been shown to cause the degradation of DNMT1 and to reactivate silenced tumor suppressor genes by reducing CpG island hypermethylation.Formal Name:...

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo...

DNMT3B (UniProtKB/Swiss Prot entry Q9UBC3) catalyses the genome wide de novo methylation of CpG residues, which regulates gene expression. DNMT3B is essential for development. DNA methylation on CpG residues is coordinated with methylation of histones. Six different isoforms of DNMT3B, produced by alternative...

Murine DNA methyltransferase 3beta (DNMT3B) (GenBank Accession No. NM_001003961), amino acids 2-859 (end), with N-terminal His-tag and C-terminal FLAG-tag, MW = 99 kDa, expressed in Sf9 cells via a Baculovirus expression system.

The DNMT3B Direct Activity Assay Kit is designed to measure DNMT3B activity using purified DNMT3B/3L or cell extracts containing DNMT3B. The DNMT3B Direct Activity Assay Kit comes in a convenient format, with a 96-well plate precoated with DNMT substrate

In 1X PBS, pH 7.4, with 0.09% sodium azide. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is...

Protein function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as...

Protein function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as...

Synonyms: DNA (Cytosine-5)-Methyltransferase 3B, DNA (Cytosine-5)-Methyltransferase 3-Like, DNA Methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB. Purity: >90% estimated by SDS-PAGE. Source: Active recombinant human N-terminal GST-tagged DNMT3B and N-terminal His-tagged DNMT3L expressed in insect cells. Amino...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. DNA (cytosine-5-)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. DNA (cytosine-5-)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. DNA (cytosine-5-)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have...