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Promotion:
Get 15% Discount on Antibodies and Biosimilars by Abeomics!
*1
*1 Offer expires 30/06/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ABE-10-7003-F-100 | 100 µg | - |
3 - 11 business days* |
15 %
|
418.00€
355.30€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for... more
Product information "Anti-DNMT3a (Clone: ABM13G4 ) FITC Conjugated"
Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring. Dnmt3a also directs a metabolic program by repressing key genes to enable the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been found in several cancers including AML (Acute Myeloid Leukemia). Protein function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [The UniProt Consortium]
Keywords: | Anti-DNMT3A, Anti-Dnmt3a, Anti-M.HsaIIIA, EC=2.1.1.37, Anti-DNA MTase HsaIIIA, Anti-DNA methyltransferase HsaIIIA, Anti-DNA (cytosine-5)-methyltransferase 3A, Monoclonal Antibody to DNMT3a (Clone: ABM13G4 ) FITC Conjugated |
Supplier: | Abeomics |
Supplier-Nr: | 10-7003-F |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | ABM13G4 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A partial length recombinant protein from DNMT3a was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K17398 | Matching products |
UniProt ID : | Q9Y6K1 | Matching products |
Gene ID | GeneID 1788 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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