72 products were found matching "K17398"!

In 1X PBS, pH 7.4, with 0.09% sodium azide. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites....

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human DNMT3A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human DNMT3A....

SGI-1027 is an inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B (IC50s = 12.5, 8, and 7.5 µM, respectively, with Poly(dI-dC) as the substrate). It has been shown to cause the degradation of DNMT1 and to reactivate silenced tumor suppressor genes by reducing CpG island hypermethylation.Formal Name:...

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three...

Anti-Dnmt3a Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Dnmt3a from human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-Dnmt3a from other sources has not been determined. Protein function: Required for...

Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the...

Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the...

Protein function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate...

DNMT3A (UniProtKB/Swiss Prot entry Q9Y6K1) catalyses the genome wide de novo methylation of CpG residues. DNA methylation on CpG residues by DNMT3A regulates gene expression and is essential for development. DNMT3A is strongly expressed in embryonic stem cells, but low in adult somatic cells. DNA methylation is...

Active humanDNMT3a (GenBank Accession No. NM_175629), (a-a 2-913), with N-terminal GST tag, MW=128 kDa, expressed in baculovirus expression system.

The DNMT3A Direct Activity Assay Kit is designed to measure DNMT3A activity using purified DNMT3A/3L or cell extracts containing DNMT3A. The DNMT3A Direct Activity Assay Kit comes in a convenient format, with a 96-well plate precoated with DNMT substrate,