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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-1068-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35.... more
Product information "Anti-CD35 / CR1 (Follicular Dendritic Cell Marker)(Clone: SPM554)"
Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This MAb is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma. Protein function: Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). [The UniProt Consortium]
Keywords: | Anti-CR1, Anti-CD35, Anti-C3BR, Anti-C3b/C4b receptor, Anti-Complement receptor type 1, Monoclonal Antibody to CD35 / CR1 (Follicular Dendritic Cell Marker)(Clone: SPM554) |
Supplier: | Abeomics |
Supplier-Nr: | 36-1068 |
Properties
Application: | FC, IF, IHC |
Antibody Type: | Monoclonal |
Clone: | SPM554 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, baboon, cynomolgus monkey, rhesus monkey |
Immunogen: | Intact human monocytes |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04011 | Matching products |
UniProt ID : | P17927 | Matching products |
Gene ID | GeneID 1378 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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