Anti-CD146 (Human), Unconjugated Clone B-T46

Specificity: Recognizes both recombinant and natural human CD146, Format: Phosphate-buffered saline with 1% BSA and 0.09% sodium azide, Working Dilution: Use 10 µl to label 106 cells or 100 µl of whole blood, Storage: Stable at +2-8°C for 12 months. DO NOT FREEZE. Protein function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [The UniProt Consortium]