Anti-CD135 / Flt3

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R32824 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cluster of differentiation antigen 135... more
Product information "Anti-CD135 / Flt3"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. [The UniProt Consortium]
Keywords: Anti-Flt3, Anti-FLK-2, Anti-Flk-2, Anti-CD135, Anti-FLT-3, EC=2.7.10.1, Anti-Fetal liver kinase 2, Anti-FL cytokine receptor, Anti-Fms-like tyrosine kinase 3, Anti-Tyrosine-protein kinase receptor flk-2, Anti-Receptor-type tyrosine-protein kinase FLT3, CD
Supplier: NSJ Bioreagents
Supplier-Nr: R32824

Properties

Application: WB, IHC (paraffin), ELISA (direct)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: mouse, rat
Immunogen: A recombinant mouse protein corresponding to amino acids E62-E295 was used as the immunogen for the Flt3 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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