261 products were found matching "K05092"!

Description: FLT3 Protein, Human, Recombinant (His) is expressed in Baculovirus Insect Cells with N-6xHis. The accession number is P36888.

A dual inhibitor of FLT3D835Y and FAK, inhibits growth of HCT116, MDA-MB-231, and A375 cells (GI50s = 0.25, 0.46, and 0.49 µM, respectively). SMILES: CS(NC1=CC=CC(C2=CSC3=C2N=C(N=C3)NC(C=C4)=CC=C4N5CCNCC5)=C1)(=O)=O. InChi Code:...

Quizartinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, Kd = 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. It inhibits the proliferation of the human leukemia cell line MV4-11, which harbors a homozygous FLT3-ITD mutation, with an IC50 value of...

Active human Flt3 (GenBank Accession No. NM_004119), (a.a. 564-end) with N-terminal His tag, MW=54.2 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA,...

Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Anticancer compound. Caspase-independent, non-apoptotic cell death inducer. ATP-competitive Flt3 inhibitor. Necrosis inducer. Aurora B and C kinase inhibitor. DYRK1A and DYRK 2 (Dual-specificity tyrosine phosphorylation-regulated...

UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines...

AC-710 is an inhibitor of PDGFR family kinases (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRbeta, CSF1R, FLT3, and c-Kit, respectively). It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC50s = >40 µM). AC-710 (30...

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...

Gilteritinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, IC50 = 5 nM for the wild-type enzyme). It inhibits mutant forms of FLT3, including FLT3 with the internal tandem duplication mutation (FLT3-ITD), FLT3-ITD expressing the F691L mutation, and FLT3 with various tyrosine kinase domain mutations...

FMS-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) are tyrosine kinases that mediate cytokine signaling and are frequently mutated in cancers, particularly acute myeloid leukemia. Pacritinib is an inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively). It also blocks the activities of the FLT3...

Fms-like tyrosine kinase (FLT3) is a cell-surface receptor with important roles in stem cell development, hematopoiesis, and cancer. FLT3 Inhibitor is a cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 µM). It is...

Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes...