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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
DC-853.860.000 | 200 µg (200 µl) | - |
3 - 8 business days* |
204.00€
|
|||
DC-853.860.005 | 500 µg (500µl) | - |
3 - 8 business days* |
432.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Specificity: Recognises Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a... more
Product information "Anti-CD130 (human), Azide Free Clone B-T2 [Mouse]"
Specificity: Recognises Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein, Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free, Storage: Store at +2-8°C for 12 months. For longer storage, freeze aliquots, Application Notes: Suitable for ELISA Protein function: Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. Also activates the yes- associated protein 1 (YAP) and NOTCH pathways to control inflammation- induced epithelial regeneration, independently of STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. [The UniProt Consortium]
Keywords: | Mouse Anti-Human CD130 Monoclonal Antibody, Azide Free Clone B-T2, Anti-gp130, Anti-CD130, Anti-IL-6RB, Anti-CDw130, Anti-IL-6R-beta, Anti-IL-6R subunit beta, Anti-Membrane glycoprotein 130, Anti-IL-6 receptor subunit beta, Anti-Interleukin-6 signal trans |
Supplier: | Diaclone |
Supplier-Nr: | 853.860 |
Properties
Application: | ELISA |
Antibody Type: | Monoclonal |
Clone: | B-T2 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Natural soluble CD130 (gp130) |
Database Information
KEGG ID : | K05060 | Matching products |
UniProt ID : | P40189 | Matching products |
Gene ID | GeneID 3572 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +20°C (International: +20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H300, H310, H410, EUH032 |
P Phrases: | P262, P264, P270, P273, P280, P321, P330, P391, P301+P310, P302+P352, P361+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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