Anti-CD105 (Endoglin, gp160, TGF beta1,3 Receptor), Biotin conjugated, clone 2Q1707

CD105/endoglin is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages and lymphoid and myeloid leukemic cells. Both mouse and human CD105 exhibit > 70% sequence homology in their cytoplasmic domains with type III transforming growth factor beta (TGFb) receptor. CD105 has been shown to be one of several receptors for the various isoforms of TGFb, which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells and control of the immune response. Applications: Suitable for use in Identification and enumeration of CD105 + cells by Flow Cytometry, Immunocytochemistry and Western Blot. Other applications have not been tested. Recommended Dilution: Flow Cytometry: < 1ug/10e6 cells, Immunocytochemistry: frozen sections, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%) aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Note: Applications are based on unconjugated antibody.