Anti-CD105 / Endoglin

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG40197.50	50 µg		-	-	6 - 14 business days*		504.00€

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Protein function: Vascular endothelium glycoprotein that plays an important role in the... more

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Product information "Anti-CD105 / Endoglin"

Protein function: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:10625534). Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed:10625534). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PubMed:28530658). May play a role in the binding of endothelial cells to integrins. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3. [The UniProt Consortium]

Keywords:	Anti-Eng, Anti-Edg, Anti-CD105, Anti-Endoglin, Anti-Cell surface MJ7/18 antigen
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40197

Properties

Application:	IHC (paraffin)
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	mouse, rat
Immunogen:	Recombinant protein corresponding to E27-L226 of Mouse CD105 / Endoglin
Format:	Antigen Affinity Purified