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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-20-1044-50 | 50 µl | - |
3 - 11 business days* |
373.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Apoptosis is related to many diseases and induced by a family of cell death receptors and their... more
Product information "Anti-Caspase-9"
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues. The Cleaved Caspase-9 polyclonal antibody preferntially recognizes (active) cleaved Caspase-9. Whereas the antibody has a strong preference for (active) cleaved Caspase-9, in some cell or tissue systems or techniques the antibody may also recognize the pro form of Caspase-9. Protein function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP). [The UniProt Consortium]
Keywords: | Anti-MCH6, Anti-CASP9, Polyclonal antibody to Caspase-9 |
Supplier: | Abeomics |
Supplier-Nr: | 20-1044 |
Properties
Application: | WB, IHC, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | dog, gerbil, human, mouse, rat |
Immunogen: | A recombinant catalytically active of human Caspase-9 protein was used as the immunogen for this antibody |
Format: | Sera |
Database Information
KEGG ID : | K04399 | Matching products |
UniProt ID : | P55211 | Matching products |
Gene ID | GeneID 842 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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