Anti-Caspase-11 (mouse), clone 8A5

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
AG-20T-0139-C100	100 µg		-		3 - 9 business days*		358.00€

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Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory... more

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Product information "Anti-Caspase-11 (mouse), clone 8A5"

Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.

Keywords:	Anti-Casp4, Anti-Casp11, EC=3.4.22.64
Supplier:	AdipoGen Life Sciences
Supplier-Nr:	AG-20T-0139

Properties

Application:	ELISA, FC, IP, WB
Antibody Type:	Monoclonal
Clone:	8A5
Conjugate:	No
Host:	Rat
Species reactivity:	mouse, rat
Immunogen:	Recombinant mouse caspase-11 (p20 fragment)
Purity:	>95%
Format:	Purified