Anti-BUB1B / BubR1, clone ABFG-2

Anti-BUB1B / BubR1, clone ABFG-2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ4759 100 µl - -

3 - 10 business days*

755.00€
 
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. 'Mitotic checkpoint... more
Product information "Anti-BUB1B / BubR1, clone ABFG-2"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. 'Mitotic checkpoint serine/threonine-protein kinase BUB1 beta,' also called BubR1, is an essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [UniProt] Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase- promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [The UniProt Consortium]
Keywords: Anti-BUBR1, Anti-BUB1B, Anti-hBUBR1, EC=2.7.11.1, Anti-Protein SSK1, Anti-Mitotic checkpoint kinase MAD3L, Anti-MAD3/BUB1-related protein kinase, Anti-Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, BUB1B Antibody / BubR1
Supplier: NSJ Bioreagents
Supplier-Nr: RQ4759

Properties

Application: WB
Antibody Type: Monoclonal
Clone: ABFG-2
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A synthetic peptide specific to human BUB1B
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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