Anti-BRD4

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-985A100 100 µl (100 µg) -

6 - 10 business days*

863.00€
 
Protein function: Chromatin reader protein that recognizes and binds acetylated histones and... more
Product information "Anti-BRD4"
Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P- TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P- TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II, these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B. Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters. [The UniProt Consortium]
Keywords: Anti-BRD4, Anti-HUNK1, Anti-Protein HUNK1, Anti-Bromodomain-containing protein 4
Supplier: Bethyl Laboratories
Supplier-Nr: A301-985A100

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Mouse, Rat, Bovine, Dog, Horse, Rabbit, Guinea Pig, Swine, Panda, Orangutan, Rhesus Monkey, Gorilla, West Indian Ocean Coelacanth, African Elephant, Chinese Hamster, Naked Mole Rat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-985A maps to a region between residue 1312 and 1362 of human bromodomain-containing protein 4 using the numbering given in entry NP_490597.1 (GeneID 23476).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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