161 products were found matching "K11722"!

Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...

Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...

The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. JQ1 displaces...

An inactive diastereomer of MZ1, has been used as a negative control for MZ1-induced degradation of BRD4. SMILES: CC1=NN=C2[C@H](CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@H](O)C3)=O)=O)=O)N=C(C6=CC=C(Cl)C=C6)C7=C(SC(C)=C7C)N21. InChi Code:...

In 1X PBS, pH 7.4, with 0.09% sodium azide. BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin...

In 1X PBS, pH 7.4, with 0.09% sodium azide. BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin...

Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...

OXF BD 02 is an inhibitor of bromodomain 1 (BD1) in bromodomain-containing protein 4 (BRD4, IC50 = 382 nM). It is selective for BRD4 BD1 over a panel of 60 bromodomain-containing proteins but does inhibit CREB-binding protein (CBP) at 25 µM. OXF BD 02 is cytotoxic to MV4-11 acute myeloid leukemia (AML) cells (IC50 =...

Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...

A BD1-selective BET inhibitor, selectively binds to BD1 over BD2 of BRD4 (Kis = 77 and 718 nM, respectively) and, to a lesser extent, BD1 of BRD3 and BRD2 over BD2 of BRD3 and BRD2 (Kis = 110, 83, 200, and 240 nM, respectively), selective for BET BD1 over CBP, PCAF, BRG1, BPTF, and BAZ2B (Kis = 775, 4,120, 6,560,...

A bivalent BRD4 inhibitor (IC50 = 5 nM) that simultaneously binds two bromodomains in BRD4, demonstrates antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma. Formulation: A solid. InChI:...

A PROTAC building block, has been used in the synthesis of PROTACs that drive RET or BRD4 degradation. Formulation: A solid. InChI: InChI=1S/C15H20N4O2.2ClH/c20-14-6-5-13(15(21)18-14)17-11-1-3-12(4-2-11)19-9-7-16-8-10-19,,/h1-4,13,16-17H,5-10H2,(H,18,20,21),2*1H. InChIKey: RLSJIUIOQYODBF-UHFFFAOYSA-N. SMILES:...