166 products were found matching "K11722"!

Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...

Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...

The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. JQ1 displaces...

PLX3618 is a monovalent direct degrader of bromodomain-containing protein 4 (BRD4). It binds to both bromodomain 1 (BD1) and BD2 of BRD4 and mediates its degradation via recruitment of the E3 ubiquitin ligase DDB1- and CUL4-associated factor 11 (DCAF11) with a half-maximal degradation concentration (DC50) value of...

Description: BRD4 Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is O60885.

An inactive diastereomer of MZ1, has been used as a negative control for MZ1-induced degradation of BRD4. SMILES: CC1=NN=C2[C@H](CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@H](O)C3)=O)=O)=O)N=C(C6=CC=C(Cl)C=C6)C7=C(SC(C)=C7C)N21. InChi Code:...

Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...

In 1X PBS, pH 7.4, with 0.09% sodium azide. BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin...

In 1X PBS, pH 7.4, with 0.09% sodium azide. BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin...

Protein function: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for...

OXF BD 02 is an inhibitor of bromodomain 1 (BD1) in bromodomain-containing protein 4 (BRD4, IC50 = 382 nM). It is selective for BRD4 BD1 over a panel of 60 bromodomain-containing proteins but does inhibit CREB-binding protein (CBP) at 25 µM. OXF BD 02 is cytotoxic to MV4-11 acute myeloid leukemia (AML) cells (IC50 =...

A BD1-selective BET inhibitor, selectively binds to BD1 over BD2 of BRD4 (Kis = 77 and 718 nM, respectively) and, to a lesser extent, BD1 of BRD3 and BRD2 over BD2 of BRD3 and BRD2 (Kis = 110, 83, 200, and 240 nM, respectively), selective for BET BD1 over CBP, PCAF, BRG1, BPTF, and BAZ2B (Kis = 775, 4,120, 6,560,...