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Promotion:
Get 15% Discount on Antibodies and Biosimilars by Abeomics!
*1
*1 Offer expires 30/06/2024
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Bcl-2 (B-cell lymphoma 2), is a member of Bcl-2 family of regulator proteins. These proteins... more
Product information "Anti-Bcl-2 (Clone: BC1)"
Bcl-2 (B-cell lymphoma 2), is a member of Bcl-2 family of regulator proteins. These proteins contain a hydrophobic cleft that binds to BH3-only proteins and to the pro-apoptotic Bcl-2 family members Bad, Bak, and Bax to inhibit apoptosis. In the absence of this binding, the proapoptotic Bcl-2 members are recruited to the OMM (Outer Mitochondrial Membrane) at which they oligomerize and cause OMM permeabilization, releasing proapoptotic effectors such as SMAC or cytochrome-c. Bcl-2 also neutralize a group of 'sensor' proteins (such as BIM), which are triggered by cytotoxic stimuli such as chemotherapy. BCL-2 proteins therefore have a central role as guardians against apoptosis, helping cancer cells to evade cell death. Protein function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). [The UniProt Consortium]
Keywords: | Anti-BCL2, Anti-Apoptosis regulator Bcl-2, Monoclonal Antibody to Bcl-2 (Clone: BC1) |
Supplier: | Abeomics |
Supplier-Nr: | 10-1052 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | BC1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A synthetic peptide corresponding to amino acids 41-54 (GAAPAPGIFSSQPG-Cys), of human Bcl-2 was used as immunogen. |
Format: | Purified |
Database Information
KEGG ID : | K02161 | Matching products |
UniProt ID : | P10415 | Matching products |
Gene ID | GeneID 596 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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