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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V7847-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V7847-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The adenomatous polyposis... more
Product information "Anti-APC / Adenomatous polyposis coli, clone ALi 12-28"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2,843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. Functions as a tumor suppressor, promoting rapid degradation of CTNNB1 and is a negative regulator of Wnt signaling. Also plays a role in HGF-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. Protein function: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)- induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. [The UniProt Consortium]
Keywords: | Anti-DP2.5, Anti-Protein APC, Anti-Deleted in polyposis 2.5, Anti-Adenomatous polyposis coli protein, APC Antibody / Adenomatous polyposis coli |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V7847 |
Properties
Application: | FC, IF, WB |
Antibody Type: | Monoclonal |
Clone: | ALi 12-28 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A recombinant human partial protein (amino acids 1-433) |
Format: | Purified |
Database Information
KEGG ID : | K02085 | Matching products |
UniProt ID : | P25054 | Matching products |
Gene ID | GeneID 324 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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