Anti-APC

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG41511.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt... more

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Product information "Anti-APC"

Protein function: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. [The UniProt Consortium]

Keywords:	Anti-DP2.5, Anti-Protein APC, Anti-Deleted in polyposis 2.5, Anti-Adenomatous polyposis coli protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG41511

Properties

Application:	IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, rat
Immunogen:	Synthetic peptide of Human APC
MW:	312 kD
Format:	Affinity Purified