Anti-AMPA Receptor 4(GluA4)

Glutamate is the major excitatory neurotransmitter and modulates its effects via ionotropic and metabotropic receptors which are different in their molecular, biochemical, pharmacological and physiological properties. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Protein function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. [The UniProt Consortium] Recommended dilutions: WB 1:500-1,000  IHC 1:200-500. Cellular localization: Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse