Anti-Activin A receptor type IB (ACVR1B, Activin receptor-like kinase 4, Activin receptor type 1B pr

Anti-Activin A receptor type IB (ACVR1B, Activin receptor-like kinase 4, Activin receptor type 1B pr
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A0855-90D.100 100 µg - -

3 - 19 business days*

511.00€
 
Activins are dimeric growth and differentiation factors which belong to the transforming growth... more
Product information "Anti-Activin A receptor type IB (ACVR1B, Activin receptor-like kinase 4, Activin receptor type 1B pr"
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions. At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Human Kidney Tissue Lysate, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-SKR1, Anti-TSR-I, Anti-ALK-2, Anti-ACVRLK2, EC=2.7.11.30, Anti-Activin receptor type-1, Anti-Activin receptor type I, Anti-Activin receptor-like kinase 2, Anti-TGF-B superfamily receptor type I, Anti-Serine/threonine-protein kinase receptor R1
Supplier: United States Biological
Supplier-Nr: A0855-90D

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to 14aa from near the carboxy terminus of the human ACVR1B.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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