Anti-Abraxas

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A302-181A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A302-181A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Involved in DNA damage response and double-strand break (DSB) repair. Component... more

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Product information "Anti-Abraxas"

Protein function: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. [The UniProt Consortium]

Keywords:	Anti-Protein FAM175A, Anti-BRCA1-A complex subunit Abraxas 1, Anti-Coiled-coil domain-containing protein 98
Supplier:	Bethyl Laboratories
Supplier-Nr:	A302-181A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: orangutan, rhesus monkey, white-tufted-ear marmoset, crab-eating macaque)
Immunogen:	synthetic peptide. The epitope recognized by A302-181A-T maps to a region between residue 400 and 409 of human Abraxas (coiled-coil domain containing 98) using the numbering given in entry NP_620775.2 (GeneID 84142).
Format:	Antigen Affinity Purified