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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
0004-01X.100 | 100 tests | - | - |
3 - 19 business days* |
632.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
4-1BB, also known as CD137 and ILA (induced by lymphocyte activation), is a TNF receptor... more
Product information "Anti-4-1BB (TNFRSF9, tumor necrosis factor receptor superfamily, member 9, 4-1BB, 4-1BB ligan"
4-1BB, also known as CD137 and ILA (induced by lymphocyte activation), is a TNF receptor superfamily member and has been designated TNFRSF9. Mouse 4-1BB cDNA encodes a 256aa residue type I transmembrane protein. A soluble 4-1BB is released from the surfaces of cells expressing the transmembrane protein. Mouse 4-1BB shares approximately 60% aa sequence identity with its human counterpart. 4-1BB is expressed on activated CD4+ and CD8+ T cells, thymocytes, and NK cells. It is also expressed on monocytes, neutrophils, dendritic cells (DCs), and eosinophils. The ligand for 4-1BB (4-1BBL), also named TNFSF9, belongs to the TNF ligand superfamily. In vivo, the co-stimulatory activity of 4-1BB has been shown to be important in graft-vs-host disease and antiviral CTL responses. On dendritic cells, 4-1BB is a DC-activating molecule that enhances cytokine production and up-regulates expression of B7-1 and B7-2 co-stimulatory molecules, resulting in an improved ability to stimulate T cell responses.1-5. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Hybridoma: Myeloma cells with B cells from Balb/c mice. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Supplier: | United States Biological |
Supplier-Nr: | 0004-01X |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | 11D95 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | mouse |
Immunogen: | Recombinant corresponding to mouse 4-1BB/TNFRSF9 extracellular domain expressed in NSO cells (P20334). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05146 | Matching products |
UniProt ID : | P20334 | Matching products |
Gene ID | GeneID 21942 | Matching products |
Handling & Safety
Storage: | +4°C (do not freeze) |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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