Anti-CD137 / 4-1BB

0.5mg/ml if reconstituted with 0.2ml sterile DI water. CD137 is a member of the tumor necrosis factor (TNF) receptor family. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. Protein function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. [The UniProt Consortium]