Amylin (human) (trifluoroacetate salt)

Amylin is a 37-residue peptide hormone secreted from pancreatic beta-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes. Amylin forms fibrils that react to thioflavin T and are organized in a cross-beta arrangement of beta-strands similar to amyloid-beta (1-40) (Abeta40, Cay-21617) and amyloid-beta (1-42) (Abeta42, Cay-20574) fibrils., Aggregated amylin (60 µM) decreases the viability of primary pancreatic islet cell cultures by 60%. It also inhibits electrically-stimulated contractions of guinea pig vas deferens (EC50 = 213 nM).Formal Name: L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-tyrosine, cyclic (2->7)-disulfide, trifluoroacetate. Synonyms: IAPP (human), Islet Amyloid Polypeptide (human). Molecular Formula: C165H260N50O56S2 . XCF3COOH. Formula Weight: 3904.3. Purity: >95%. Formulation: (Request formulation change), A powder. Solubility: Formic Acid: 1 mg/ml. SMILES: [H]N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C1=O)=O)C)=O)=O)=O)CSSC[C@H](N1)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(O)=O)CC2=CC=C(O)C=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)CC4=CN=CN4)=O)=O)=O)CC5=CC=CC=C5)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C165H260N50O56S2.C2HF3O2/c1-22-75(12)124(158(264)198-94(47-71(4)5)139(245)202-108(64-218)152(258)205-110(66-220)153(259)215-128(83(20)224)161(267)200-104(58-119(174)233)146(252)208-122(73(8)9)156(262)180-61-121(235)186-106(62-216)149(255)196-102(56-117(172)231)147(253)214-129(84(21)225)162(268)201-105(164(270)271)51-87-38-40-89(226)41-39-87)210-131(237)76(13)182-120(234)60-179-135(241)96(49-85-32-25-23-26-33-85)192-143(249)100(54-115(170)229)194-144(250)101(55-116(171)230)195-150(256)107(63-217)204-151(257)109(65-219)203-141(247)98(52-88-59-177-69-181-88)199-157(263)123(74(10)11)209-145(251)95(48-72(6)7)191-140(246)97(50-86-34-27-24-28-35-86)193-142(248)99(53-114(169)228)189-130(236)77(14)183-138(244)93(46-70(2)3)190-136(242)91(37-31-45-178-165(175)176)187-137(243)92(42-43-113(168)227)188-160(266)126(81(18)222)211-132(238)78(15)184-154(260)111-67-272-273-68-112(206-134(240)90(167)36-29-30-44-166)155(261)197-103(57-118(173)232)148(254)213-125(80(17)221)159(265)185-79(16)133(239)212-127(82(19)223)163(269)207-111,3-2(4,5)1(6)7/h23-28,32-35,38-41,59,69-84,90-112,122-129,216-226H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,227)(H2,169,228)(H2,170,229)(H2,171,230)(H2,172,231)(H2,173,232)(H2,174,233)(H,177,181)(H,179,241)(H,180,262)(H,182,234)(H,183,244)(H,184,260)(H,185,265)(H,186,235)(H,187,243)(H,188,266)(H,189,236)(H,190,242)(H,191,246)(H,192,249)(H,193,248)(H,194,250)(H,195,256)(H,196,255)(H,197,261)(H,198,264)(H,199,263)(H,200,267)(H,201,268)(H,202,245)(H,203,247)(H,204,257)(H,205,258)(H,206,240)(H,207,269)(H,208,252)(H,209,251)(H,210,237)(H,211,238)(H,212,239)(H,213,254)(H,214,253)(H,215,259)(H,270,271)(H4,175,176,178),(H,6,7)/t75-,76-,77-,78-,79-,80+,81+,82+,83+,84+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-,127-,128-,129-,/m0./s1. InChi Key: VGLYYFSTHMXVQZ-MUEVRUHOSA-N.