Substrates and Inhibitors

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alpha-Bungarotoxin
alpha-Bungarotoxin

Item number: Cay16385-1

alpha-Bungarotoxin is a snake venom-derived toxin that irreversibly binds nicotinic acetylcholine receptors (Ki = ~2.5 µM in rat) present in skeletal muscle, blocking action of acetylcholine at the postsynaptic membrane and leading to paralysis. It has been widely used to characterize activity at the neuromuscular...
Keywords: alpha-Bgt, alpha-BTX, alpha-bungarotoxin
Application: Irreversible nicotinic acetylcholine receptor blocker
CAS 11032-79-4
MW: 7984.2 D
187.00€ *
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Pepstatin
Pepstatin

Item number: LKT-P1761.25

An inhibitor of acid proteases isolated from streptomyces. It has been shown to induce contractile effects on rat aorta rings.
Keywords: Pepstatin A
Application: Aspartyl Protease inhibitor
CAS 26305-03-3
MW: 685,89 D
From 91.00€ *
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Ac-DEVD-CHO
Ac-DEVD-CHO

Item number: ABD-13403

A reversible inhibitor of IL-1 converting enzyme (ICE), inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).
Application: Caspase-3 (ICE) inhibitor
CAS 169332-60-9
108.00€ *
Review
Ac-DEVD-pNA
Ac-DEVD-pNA

Item number: ABD-13405

A colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Application: Caspase-3 substrate
CAS 189950-66-1
108.00€ *
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Ac-DEVD-AFC
Ac-DEVD-AFC

Item number: ABD-13401

A fluorogenic substrate for caspase 3. The 7-amido-4-trifluoromethylcoumarin derivatives have better membrane permeability than the 7-amido-4-methylcoumarin derivatives.
Application: Caspase-3 substrate
CAS 201608-14-2
108.00€ *
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Ac-IETD-AFC
Ac-IETD-AFC

Item number: ABD-13410

A fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety.
Application: Caspase-8 substrate
CAS 211990-57-7
221.00€ *
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(Z-DEVD)2-R110
(Z-DEVD)2-R110

Item number: ABD-13430

Cleavage of R110 peptides by caspases generates strongly fluorescent R110 that can be monitored fluorimetrically at 510-530 nm with excitation of 488 nm.This R110 substrate is specific for caspases 3 and 7.
Application: Caspase-3 substrate, Caspase-7 substrate
108.00€ *
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(BOC-VPR)2R110
(BOC-VPR)2R110

Item number: ABD-13462

(BOC-VPR)2R110 is a sentive fluorogenic substrate for alpha-thrombin. The non-fluorescent substrate generates a bright green fluorescent R110 product that has Ex/Em = 495/520 nm, and can be easily detected with the FITC filter set. This substrate has also been used for the rapid detection of MRSA...
Application: Fluorogenic alpha-thrombin substrate
108.00€ *
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(Ac-KQL)2R110
(Ac-KQL)2R110

Item number: ABD-13465

The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
Application: Protease substrate
108.00€ *
Review
(Z-LLE)2R110
(Z-LLE)2R110

Item number: ABD-13466

The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
Application: Protease substrate
108.00€ *
Review
Ac-DEVD-AMC
Ac-DEVD-AMC

Item number: ABD-13402

A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Application: Caspase-3 substrate
CAS 169332-61-0
108.00€ *
Review
(Ac-WLA)2R110
(Ac-WLA)2R110

Item number: ABD-13468

The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
Application: Protease substrate
108.00€ *
Review
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