Substrates and Inhibitors

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Ac-DEVD-AFC
Ac-DEVD-AFC

Item number: ABD-13401

A fluorogenic substrate for caspase 3. The 7-amido-4-trifluoromethylcoumarin derivatives have better membrane permeability than the 7-amido-4-methylcoumarin derivatives.
Application: Caspase-3 substrate
CAS 201608-14-2
112.00€ *
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(Z-DEVD)2-R110
(Z-DEVD)2-R110

Item number: ABD-13430

Cleavage of R110 peptides by caspases generates strongly fluorescent R110 that can be monitored fluorimetrically at 510-530 nm with excitation of 488 nm.This R110 substrate is specific for caspases 3 and 7.
Application: Caspase-3 substrate, Caspase-7 substrate
112.00€ *
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Ac-DEVD-AMC
Ac-DEVD-AMC

Item number: ABD-13402

A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Application: Caspase-3 substrate
CAS 169332-61-0
112.00€ *
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(Ac-PAL)2R110
(Ac-PAL)2R110

Item number: ABD-13467

The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
Application: Protease substrate
112.00€ *
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NEW
MCL-1 Peptide Ligand
MCL-1 Peptide Ligand

Item number: BPS-79507

MCL-1 Peptide Ligand is useful as a substrate for screening services and optimized for use with the following TR-FRET assay kits: * MCL-1 TR-FRET Assay kit (BPS-79506) * MCL-1 TR-FRET Assay kit (Mouse) (BPS-79928)
Application: Substrate, Screening, TR-FRET
MW: 3162 D
247.00€ *
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Ac-QPKK(Ac)-AMC
Ac-QPKK(Ac)-AMC

Item number: Cay30790-1

Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3. It is selectively deacylated by SIRT1-3 over SIRT6. Upon enzymatic cleavage by SIRT1, SIRT2, or SIRT3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify SIRT1, SIRT2, and SIRT3 activity. AMC...
Keywords: Ac-Gln-Pro-Lys-Lys-(Ac)-7-amino-4-methylcoumarin, Ac-Gln-Pro-Lys-Lys-(Ac)-AMC, p53317-320 Substrate (Ac-QPKK(Ac)-AMC),...
Application: Fluorogenic SIRT1 substrate
CAS 1387005-23-3
MW: 740.9 D
From 74.00€ *
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Z-(L-Arg)-AMC (hydrochloride)
Z-(L-Arg)-AMC (hydrochloride)

Item number: Cay30797-10

Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H. Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation/emission...
Keywords: Bz-Arg-AMC, N-benzoxy-L-Arg-7-amido-4-methylcoumarin, N-benzoyl-L-Arg-AMC, Z-Arg(HCl)AMC,...
Application: Fluorogenic trypsin substrate
CAS 70375-22-3
MW: 502 D
From 69.00€ *
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RR-Src (trifluoroacetate salt)
RR-Src (trifluoroacetate salt)

Item number: Cay33579-1

RR-Src is a synthetic peptide substrate that corresponds to the sequence in Src surrounding the tyrosine subject to phosphorylation. It is a substrate for EGF-mediated tyrosine phosphorylation. RR-Src inhibits IL-2-induced proliferation of cytotoxic T cells.Formal Name:...
Keywords: Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, RRLIEDAEYAARG, Src-Peptide,...
Application: Synthetic peptide substrate
MW: 1519.7 D
From 62.00€ *
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Bortezomib
Bortezomib

Item number: Cay10008822-5

Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM). It binds the beta5-subunit of the 20S proteasome and selectively inhibits chymotryptic activity. In part by blocking the degradation of tumor-suppressing and proapoptotic proteins, bortezomib drives cell...
Keywords: LDP-341, MG-341, MLN341, NSC 681239, PS-341,...
Application: Proteasome subunit beta type-1/5 inhibitor
CAS 179324-69-7
MW: 384.2 D
From 32.00€ *
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(BOC-VPR)2R110
(BOC-VPR)2R110

Item number: ABD-13462

(BOC-VPR)2R110 is a sentive fluorogenic substrate for alpha-thrombin. The non-fluorescent substrate generates a bright green fluorescent R110 product that has Ex/Em = 495/520 nm, and can be easily detected with the FITC filter set. This substrate has also been used for the rapid detection of MRSA...
Application: Fluorogenic alpha-thrombin substrate
112.00€ *
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(Ac-WLA)2R110
(Ac-WLA)2R110

Item number: ABD-13468

The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
Application: Protease substrate
112.00€ *
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Pepstatin
Pepstatin

Item number: LKT-P1761.25

An inhibitor of acid proteases isolated from streptomyces. It has been shown to induce contractile effects on rat aorta rings.
Keywords: Pepstatin A
Application: Aspartyl Protease inhibitor
CAS 26305-03-3
MW: 685,89 D
From 91.00€ *
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