Substrates and Inhibitors

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Ac-IETD-AFC
Ac-IETD-AFC

Item number: ABD-13410

A fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety.
Application: Caspase-8 substrate
CAS 211990-57-7
211.00€
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Z-AEVD-FMK
Z-AEVD-FMK

Item number: Cay14987-500

Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases. At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.
Keywords: Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone,...
Application: Irreversible caspase-10 inhibitor
CAS 1135688-47-9
MW: 610.6 D
From 69.00€
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Ac-LETD-AFC
Ac-LETD-AFC

Item number: Cay14991-5

Ac-LETD-AFC is a fluorogenic substrate that can be cleaved specifically by caspase-8. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
Keywords: Caspase-8 Substrate (Fluorogenic), N-Acetyl-Leu-Glu-Thr-Asp-7-amido-4-Trifluoromethylcoumarin,...
Application: Fluorogenic Caspase-8 substrate
CAS 210345-02-1
MW: 729.7 D
From 78.00€
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alpha-Bungarotoxin
alpha-Bungarotoxin

Item number: Cay16385-1

alpha-Bungarotoxin is a snake venom-derived toxin that irreversibly binds nicotinic acetylcholine receptors (Ki = ~2.5 µM in rat) present in skeletal muscle, blocking action of acetylcholine at the postsynaptic membrane and leading to paralysis. It has been widely used to characterize activity at the neuromuscular...
Keywords: alpha-Bgt, alpha-BTX, alpha-bungarotoxin
Application: Irreversible nicotinic acetylcholine receptor blocker
CAS 11032-79-4
MW: 7984.2 D
187.00€
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Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp
Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp

Item number: Cay16467-1

Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm, em = 420 nm).
Keywords: N-(2-aminobenzoyl)-L-alanyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-methionyl-L-arginyl-L-arginyl-N1-[2-[...
Application: Neutrophil elastase substrate
CAS 824405-61-0
MW: 1456.6 D
249.00€
Review
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp

Item number: Cay9002021-1

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm, em = 420 nm).
Keywords: N-(2-aminobenzoyl)-L-valyl-L-alanyl-L-alpha-aspartyl-L-norvalyl-L-arginyl-L-alpha-aspartyl-L-arginyl-N1-[2-[(2,4-dinitroph...
Application: Fluorescence-quenched proteinase 3 substrate
CAS 1042405-14-0
MW: 1285.3 D
269.00€
Review
Aeruginosin 722
Aeruginosin 722

Item number: LKT-A1890.100

Aeruginosins are tetrapeptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosins inhibit serine/threonine protein phosphatases (PPs). In endothelial cells, aeruginosins decrease levels of IL-8 and ICAM-1 and inhibit NF-kappaB activity. Aeruginosins may also bind...
Application: Protein phosphatase inhibitor
MW: 723.24 D
844.00€
Review
Aeruginosamide B
Aeruginosamide B

Item number: LKT-A1895.100

Aeruginosamides are linear ribosomal peptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosamides may inhibit serine/threonine protein phosphatases (PPs) or exhibit antithrombotic activity.
Application: Protein phosphatase inhibitor
MW: 574.73 D
396.00€
Review
Aeruginosamide C
Aeruginosamide C

Item number: LKT-A1896.100

Aeruginosamides are linear ribosomal peptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosamides may inhibit serine/threonine protein phosphatases (PPs) or exhibit antithrombotic activity.
Application: Protein phosphatase inhibitor
MW: 673.86 D
396.00€
Review
Aeruginosamide D
Aeruginosamide D

Item number: LKT-A1897.100

Aeruginosamides are linear ribosomal peptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosamides may inhibit serine/threonine protein phosphatases (PPs) or exhibit antithrombotic activity.
Application: Protein phosphatase inhibitor
MW: 560.71 D
594.00€
Review
Aeruginosamide E
Aeruginosamide E

Item number: LKT-A1898.100

Aeruginosamides are linear ribosomal peptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosamides may inhibit serine/threonine protein phosphatases (PPs) or exhibit antithrombotic activity.
Application: Protein phosphatase inhibitor
MW: 659.84 D
594.00€
Review
Anabaenopeptin A
Anabaenopeptin A

Item number: LKT-A5200.100

Anabaenopeptins are cyclopentapeptides isolated from cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine/threonine protein phosphatases (PPs). Anabaenopeptins may also inhibit carboxypeptidases. Anabaenopeptins B and F are...
Application: Protein phosphatase inhibitor
CAS 161897-73-0
MW: 843.96 D
396.00€
Review
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