Substrates and Inhibitors

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Z-AEVD-FMK
Z-AEVD-FMK

Item number: Cay14987-500

Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases. At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.
Application: Irreversible caspase-10 inhibitor
CAS 1135688-47-9
MW: 610.6 D
Purity: >95%
Format: Crystalline Solid
From 69.00€
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Ac-LETD-AFC
Ac-LETD-AFC

Item number: Cay14991-5

Ac-LETD-AFC is a fluorogenic substrate that can be cleaved specifically by caspase-8. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
Application: Fluorogenic Caspase-8 substrate
CAS 210345-02-1
MW: 729.7 D
Purity: >95%
Format: Crystalline Solid
From 78.00€
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Gly-Pro-pNA (hydrochloride)
Gly-Pro-pNA (hydrochloride)

Item number: Cay21244-25

Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm. DPP IV inactivates the two peptides responsible for a majority of nutrient-stimulated insulin secretion: glucose-dependent insulinotropic polypeptide (GIP) and...
Application: Chromogenic DPP4 substrate
CAS 103213-34-9
MW: 328.8 D
Purity: >98%
Format: Crystalline Solid
From 35.00€
Review
alpha-Bungarotoxin
alpha-Bungarotoxin

Item number: Cay16385-1

alpha-Bungarotoxin is a snake venom-derived toxin that irreversibly binds nicotinic acetylcholine receptors (Ki = ~2.5 µM in rat) present in skeletal muscle, blocking action of acetylcholine at the postsynaptic membrane and leading to paralysis. It has been widely used to characterize activity at the neuromuscular junction, which has numerous applications in neuroscience...
Application: Irreversible nicotinic acetylcholine receptor blocker
CAS 11032-79-4
MW: 7984.2 D
Purity: >99%
Format: Solid
187.00€
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Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp
Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp

Item number: Cay16467-1

Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm, em = 420 nm).
Application: Neutrophil elastase substrate
CAS 824405-61-0
MW: 1456.6 D
Purity: >95%
Format: Solid
249.00€
Review
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp

Item number: Cay9002021-1

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm, em = 420 nm).
Application: Fluorescence-quenched proteinase 3 substrate
CAS 1042405-14-0
MW: 1285.3 D
Purity: >98%
Format: Solid
249.00€
Review
Aeruginosin 722
Aeruginosin 722

Item number: LKT-A1890.100

Aeruginosins are tetrapeptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosins inhibit serine/threonine protein phosphatases (PPs). In endothelial cells, aeruginosins decrease levels of IL-8 and ICAM-1 and inhibit NF-kappaB activity. Aeruginosins may also bind thrombin and exhibit antithrombotic activity.
Application: Protein phosphatase inhibitor
MW: 723.24 D
Format: Solid
844.00€
Review
Aeruginosamide B
Aeruginosamide B

Item number: LKT-A1895.100

Aeruginosamides are linear ribosomal peptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosamides may inhibit serine/threonine protein phosphatases (PPs) or exhibit antithrombotic activity.
Application: Protein phosphatase inhibitor
MW: 574.73 D
Format: Solid
396.00€
Review
Aeruginosamide C
Aeruginosamide C

Item number: LKT-A1896.100

Aeruginosamides are linear ribosomal peptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosamides may inhibit serine/threonine protein phosphatases (PPs) or exhibit antithrombotic activity.
Application: Protein phosphatase inhibitor
MW: 673.86 D
Format: Solid
396.00€
Review
Aeruginosamide D
Aeruginosamide D

Item number: LKT-A1897.100

Aeruginosamides are linear ribosomal peptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosamides may inhibit serine/threonine protein phosphatases (PPs) or exhibit antithrombotic activity.
Application: Protein phosphatase inhibitor
MW: 560.71 D
Format: Solid
594.00€
Review
Aeruginosamide E
Aeruginosamide E

Item number: LKT-A1898.100

Aeruginosamides are linear ribosomal peptides isolated from cyanobacteria such as Microcystis aeruginosa. Like other cyanotoxins, aeruginosamides may inhibit serine/threonine protein phosphatases (PPs) or exhibit antithrombotic activity.
Application: Protein phosphatase inhibitor
MW: 659.84 D
Format: Solid
594.00€
Review
Anabaenopeptin A
Anabaenopeptin A

Item number: LKT-A5200.100

Anabaenopeptins are cyclopentapeptides isolated from cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine/threonine protein phosphatases (PPs). Anabaenopeptins may also inhibit carboxypeptidases. Anabaenopeptins B and F are considered "nontoxic" compared to other variants.
Application: Protein phosphatase inhibitor
CAS 161897-73-0
MW: 843.96 D
Format: Solid
396.00€
Review
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