Amylin (human) (amidated) (trifluoroacetate salt)

Amylin is a peptide hormone secreted from pancreatic beta-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. Native amylin is a cleavage product of proamylin that is processed and amidated at the C-terminus, a modification that is required for its biological activities. Amidated amylin increases the rate of glycogen synthesis induced by insulin in isolated rat soleus muscle when used at a concentration of 1 nM, while linear non-amidated amylin has no effect. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes and, in vitro, amidated amylin is more amyloidogenic than the free acid form. Amylin (human) (amidated) is a 37-residue amidated form of amylin that contains a disulfide bridge between cysteines two and seven.Formal Name: cyclic (2->7)-disulfide, L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-tyrosinamide, trifluoroacetate salt. Synonyms: IAPP (human) (amidated), Islet Amyloid Polypeptide (human) (amidated). Molecular Formula: C165H261N51O55S2 . XCF3COOH. Formula Weight: 3903.3. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(N)=O)NC([C@H](CO)NC(CNC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@H](CO)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC(CNC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CO)NC([C@@H](NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](N1)CSSC[C@H](NC([C@H](CCCCN)N[H])=O)C(N[C@@H](CC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C1=O)=O)C)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)CC2=CC=CC=C2)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C165H261N51O55S2.C2HF3O2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111,3-2(4,5)1(6)7/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179),(H,6,7)/t75-,76-,77-,78-,79-,80+,81+,82+,83+,84+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-,127-,128-,129-,/m0./s1. InChi Key: ZBNJPSDLPXTHJR-MUEVRUHOSA-N.