Peptides

CAQK targeting/delivery peptide (CAQK peptide) is a four-amino acid synthetic peptide that interacts with versican and tenascin-R, proteoglycans that are upregulated in the brain extracellular matrix (ECM) in CNS injuries. Intravenous administration of CAQK peptide leads to its accumulation in injured brain tissue...

Mc-Ala-Ala-PAB is a peptide linker molecule that has been used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds. Mc-Ala-Ala-PAB has been used...

Tripeptide-41 is a cosmeceutical peptide.. SMILES: OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CC3=CNC4=CC=CC=C34)=O.OC(C)=O. InChi Code:...

Oligopeptide-20 is a peptide that corresponds to amino acids 55-66 of mature insulin-like growth factor 1 (IGF-1). It increases growth of keratinocytes and fibroblasts and the levels of procollagen, laminin, and fibronectin in keratinocytes. Oligopeptide-20 (100 mg/animal), as part of a peptide nanosome-based skin...

Acetyl hexapeptide-49 is an antagonist of proteinase-activated receptor 2 (PAR2). It inhibits PAR2 agonist-induced calcium release and calcitonin gene-related peptide (CGRP) and IL-6 production in human keratinocytes. Acetyl hexapeptide-49 also induces proliferation in human keratinocytes and has photoprotective...

Diaminopropionyl tripeptide-33 is a peptide containing alanine, proline, and histidine and modified with a 2,3-diaminopropionyl (DAP) group.. SMILES: C[C@H](NC(C(N)CN)=O)C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CN=CN2)=O)=O.CC(O)=O. InChi Code:...

(R)-Macrophage-activating lipopeptide 2 ((R)-MALP-2) is an agonist of toll-like receptor 2 (TLR2) and TLR6 and a synthetic lipopeptide derivative of M. fermentans MALP-2 that contains palmitic acid (Cay-10006627, Cay-43561) at both acyl chain positions on the glycerol moiety. It is selective for TLR2/6 over TLR2/1...

RP-182 is a synthetic innate defense regulator (IDR) peptide. It binds to CD206 (Kd = 8.37 µM for the human receptor) and induces its closed conformation with an EC50 value of ~11 µM. RP-182 selectively induces phagocytosis, autophagy, and apoptosis in M2 over M1 macrophages. It increases survival and decreases the...

Histatin 1 is an endogenous peptide secreted by the salivary glands. It accelerates wound closure in a scratch assay using TR146 epithelial-like cells and increases adhesion, migration, and the formation of vascular networks in human umbilical vein endothelial cells (HUVECs) and EA.hy926 endothelial cells. Histatin...

Insulin peptide is a dominant immunogenic T cell epitope involved in the pathogenesis of type 1 diabetes. It binds to HLA-DQ8 and I-Ag7 from non-obese diabetic (NOD) mice. Insulin peptide induces proliferation in a lymph node proliferation assay using lymph node cells isolated from NOD mice immunized with insulin...

Insulin peptide (C19S) is a peptide fragment of insulin with a single amino acid variant (SAV) of cysteine-to-serine at position 19 that corresponds to residues 32-57 of full-length insulin. It is formed post-translationally via a process driven by oxidative stress in the islet microenvironment. Insulin peptide...

SPACE peptide is a skin-penetrating and cell-entering (SPACE) peptide. It is internalized in keratinocytes, fibroblasts, human umbilical vein endothelial cells (HUVECs), and MDA-MB-231 breast cancer cells via macropinocytosis, a form of endocytosis. SPACE peptide-containing conjugates have been used to deliver...