RP-182 (trifluoroacetate salt)

RP-182 is a synthetic innate defense regulator (IDR) peptide. It binds to CD206 (Kd = 8.37 µM for the human receptor) and induces its closed conformation with an EC50 value of ~11 µM. RP-182 selectively induces phagocytosis, autophagy, and apoptosis in M2 over M1 macrophages. It increases survival and decreases the percentage of stromal CD206+ cells in the tumor microenvironment in a KP16 mouse model of pancreatic cancer. RP-182 decreases renal macrophage and neutrophil infiltration in a mouse model of unilateral ureteral obstruction-induced renal fibrosis.. SMILES: NCCCC[C@H](N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C69H103N19O11.C2HF3O2/c1-44(80-60(91)50(31-15-18-36-71)81-62(93)52(33-20-38-78-68(74)75)84-65(96)55(41-46-24-8-3-9-25-46)86-59(90)49(73)30-14-17-35-70)58(89)85-54(40-45-22-6-2-7-23-45)64(95)83-51(32-16-19-37-72)61(92)82-53(34-21-39-79-69(76)77)63(94)87-56(42-47-26-10-4-11-27-47)66(97)88-57(67(98)99)43-48-28-12-5-13-29-48,3-2(4,5)1(6)7/h2-13,22-29,44,49-57H,14-21,30-43,70-73H2,1H3,(H,80,91)(H,81,93)(H,82,92)(H,83,95)(H,84,96)(H,85,89)(H,86,90)(H,87,94)(H,88,97)(H,98,99)(H4,74,75,78)(H4,76,77,79),(H,6,7)/t44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,/m0./s1. InChi Key: USIXGOXRVLSKCK-WACKLBOQSA-N