Platelet Factor-4 (CXCL4) Variant-1, His-Tag, human recombinant (rHuPF4variant-His)

Platelet Factor-4 (CXCL4) Variant-1, His-Tag, human recombinant (rHuPF4variant-His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
97332.1 1 µg - -

3 - 10 business days*

71.00€
97332.5 5 µg - -

3 - 10 business days*

184.00€
97332.50 50 µg - -

3 - 10 business days*

1,681.00€
 
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it... more
Product information "Platelet Factor-4 (CXCL4) Variant-1, His-Tag, human recombinant (rHuPF4variant-His)"

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. (www.uniprot.org) Recombinant human CXCL4 Variant-1 produced in E.coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa. The CXCL4 Variant-1 is fused to 6xHis tag at N-Terminus. Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

Keywords: CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298
Supplier: Biomol GmbH
Supplier-Nr: 97332

Properties

Application: Bioassay
Conjugate: No
Expressed in: E.coli
Origin: Human
MW: 8700 D
Format: Purified

Database Information

KEGG ID : K05407 | Matching products
UniProt ID : P02776 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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