Platelet Factor 4, human recombinant (rHuPF-4)

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated polypeptide chain containing 70 amino acids