Recombinant Cytokines

Has antiviral, antibacterial and anticancer activities. (www.uniprot.org) Produced in CHO cells. Single, glycosylated polypeptide chain containing 166 amino acids. The specific activity as determined in a viral resistance assay was found to be 270 x 106 IU/ mg.

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release...

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. (www.uniprot.org) Produced in CHO cells. Single polypeptide chain containing 165 amino acids. Predicted molecular mass of 21,000 Dalton and...

Authentic recombinant human protein, human cell expressed, which in general ensures proper folding, phosphorylation, disulfide bridge formation, proteolytic processing, and glycosylation. Endotoxin <0.1 EU/µg.

Authentic recombinant human protein, human cell expressed, which in general ensures proper folding, phosphorylation, disulfide bridge formation, proteolytic processing, and glycosylation. Endotoxin <0.5 EU/µg.

Biologically active. Produced in Yeast. Amino acid sequence: QPDAINSPVT CCYTLTSKKI SMQRLMSYRR VTSSKCPKEA VIFKTIAGKE ICAEPKQKWV QDSISHLDKK NQTPKP. Protein function: Chemotactic factor that attracts monocytes, but not neutrophils. [The UniProt Consortium]

Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of...

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds...

Human recombinant Interleukin-10 produced in HEK cells is a glycosylated non-disulfide bonded homodimer, having a total molecular weight of 17kDa. IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It...

Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. (www.uniprot.org) Produced in E.coli. Non-glycosylated, polypeptide chain containing 144 amino acids. The activity is determined by the ability to generate...

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells...

Human recombinant IL-12 p40 produced in Hi-5 cell using Baculovirus is a single polypeptide chain containing 315 amino acids (23-328) and having a molecular mass of 29.4kDa. Active IL-12 is a p70 disulphide-linked dimer composed of p35 and p40 subunits. The protein is a pleiotropic cytokine produced primarily by...