Recombinant Human C-X-C Motif Chemokine 4/CXCL4/PF4 (C-6His)

Recombinant Human C-X-C Motif Chemokine 4/CXCL4/PF4 (C-6His)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-32-8504-10 10 µg - -

3 - 11 business days*

478.00€
ABE-32-8504-50 50 µg - -

3 - 11 business days*

791.00€
 
Source: Human Cells. MW :8.5kD. Recombinant Human C-X-C Motif Chemokine 4 is produced by our... more
Product information "Recombinant Human C-X-C Motif Chemokine 4/CXCL4/PF4 (C-6His)"
Source: Human Cells. MW :8.5kD. Recombinant Human C-X-C Motif Chemokine 4 is produced by our Mammalian expression system and the target gene encoding Glu32-Ser101 is expressed with a 6His tag at the C-terminus. Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes. Protein function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. [The UniProt Consortium]
Supplier: Abeomics
Supplier-Nr: 32-8504

Properties

Conjugate: No

Handling & Safety

Storage: +20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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