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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10009763-1 | 1 each | - |
6 - 10 business days* |
564.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
There is accumulating evidence to suggest that progesterone plays an essential role in the... more
Product information "Anti-Progesterone Receptor (Phospho-Ser294)"
There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.Immunogen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor. Formulation: (Request formulation change), Peptide affinity-purified antibody. Host: Mouse. Applications: WB and IHC (frozen sections). Origin: Animal/Mouse.
Keywords: | Anti-phospho-PR, Anti-phospho-PGR, Anti-phospho-NR3C3, Anti-phospho-Progesterone receptor, Anti-phospho-Nuclear receptor subfamily 3 group C member 3 (pS294) |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10009763 |
Properties
Application: | WB, IHC (frozen) |
Antibody Type: | Monoclonal |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor |
Format: | Solid |
Database Information
KEGG ID : | K08556 | Matching products |
UniProt ID : | P06401 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H316, H319 |
P Phrases: | P264, P280, P305+351+338, P332+313, P337+313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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