268 products were found matching "K08556"!

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.

A progesterone receptor antagonist. It is an effective late post-coital contraceptive. Active against ovarian cancer, and induces apoptosis through modulation of HPV E6/E7 in dexamethasone treated cervical cacinoma cells.

Mifepristone is an antagonist of glucocorticoid, progesterone, and androgen receptors (Kis = 0.1, 0.64, and 0.65 nM, respectively). It is selective for these receptors over the mineralocorticoid receptor (MR), estrogen receptor alpha (ERalpha), and ERbeta (Kis = 640, >200, and >750 nM, respectively). In cell-based...

Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Delta4,5-isomerase in the outer mitochondrial membrane and smooth...

16-Dehydroprogesterone is a progestin and an active metabolite of pregnenolone (Cay-19864). It inhibits the proliferation of HL-60 leukemia and U937 lymphoma cells (IC50s = 10. and 3. µM, respectively). 16-Dehydroprogesterone (2 mg/kg), in combination with gonadotropin, increases ovary and uterine weights in...

Progesterone-d9 is intended for use as an internal standard for the quantification of progesterone (Cay-15876) by GC- or LC-MS. Progesterone is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which...

Danazol is a derivative of testosterone (Cay-15645) and ethisterone that can bind to androgen receptors and sex hormone-binding globulin causing a 3-fold increase in free testosterone. It possesses weak androgenic effects and inhibits the production of gonadotropins. It has been used to address symptoms of...

Medroxyprogesterone 17-acetate is a synthetic progestogen.,, It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation. Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the...

Norethynodrel is a synthetic progestin. In vivo, norethynodrel (10 mg/animal per day) reduces fetal implantation and induces fetal resorption in mated female rats. Formulations containing norethynodrel have been used as oral contraceptives.Formal Name: 17alpha-hydroxy-19-norpregn-5(10)-en-20-yn-3-one. CAS Number:...

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the full-length human progesterone receptor (NR3C3), a ligand-dependent transcription factor commonly referred to as PR. INDIGO's reporter cells include the luciferase reporter gene...

Norethindrone is a synthetic progestin. In vivo, norethindrone (0.5 mg/animal per day) inhibits the estrous cycle in female mice. It induces tumor progression and metastasis in a BT474 breast cancer mouse xenograft model. Formulations containing norethindrone have been used as oral contraceptives.Formal Name:...

Drospirenone is a synthetic progestogen that binds to the progesterone, mineralocorticoid, and androgen receptors with binding affinities of 20, 230, and 65% relative to R5020, aldosterone (Cay-15273), and R1881, respectively. In vivo, drospirenone inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day) when...