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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-12-4260-200 | 200 µl | - |
3 - 11 business days* |
921.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Stat5 activation occurs in response to many ligands including prolactin, IL-2, growth hormone,... more
Product information "Anti-phospho-Stat5 (Tyr694) (Clone: G11) rabbit mAb"
Stat5 activation occurs in response to many ligands including prolactin, IL-2, growth hormone, and GM-CSF. Tyr694 phosphorylation is obligatory activation of Stat5 (1,2), and is mediated by Src upon erythropoietin stimulation (3). Phospho Stat5 is constitutively active in some leukemic cell types (4), and phospho Stat5 is found in some endothelial cells when treated with IL-3, suggesting its involvement in cell motility and angiogenesis (5). Stat5 has been shown to be encoded by two separate genes, Stat5a and Stat5b, which share over 90% amino acid sequence identity. In different cell types, Stat5a and Stat5b are independently regulated and activated. For example, interferon treatment predominantly activates Stat5a in U937 cells and Stat5b in HeLa cells (6). Protein function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL- induced transcription. Regulates the expression of milk proteins during lactation. [The UniProt Consortium]
Keywords: | Anti-phospho-STAT5, Anti-phospho-STAT5A, Anti-phospho-Signal transducer and activator of transcription 5A, Phospho-Stat5 (Tyr694) (Clone: G11) rabbit mAb |
Supplier: | Abeomics |
Supplier-Nr: | 12-4260 |
Properties
Application: | FC, WB |
Antibody Type: | Monoclonal |
Clone: | Stat5Y694-G11 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Database Information
KEGG ID : | K11223 | Matching products |
UniProt ID : | P42229 | Matching products |
Gene ID | GeneID 6776 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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